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NEUROENDOCRINOLOGY

Masterful papers that broke open understanding of reproductive neuroendocrinology

Nature Reviews Endocrinology volume 18, page 520 (2022)Cite this article

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In the control mechanisms of reproductive function, the biggest unknown was the details of the mechanisms that directly received sex steroid hormone feedback.

Papers published in 2003 by de Roux et al. and Seminara et al. made key contributions to understanding this issue. de Roux and colleagues reported that a homozygous deletion of 155 nucleotides in GPR54 in a consanguineous family of eight children resulted in hypogonadotropic hypogonadism. Seminara et al. also demonstrated the same results using genetically modified mice with a similar partial deletion of GPR54, which resulted in failure to express puberty, leading to reproductive dysfunction.

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References

Original articles

  • de Roux, N. et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc. Natl Acad. Sci. USA 100, 10972–10976 (2003)

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  • Seminara, S. B. et al. The GPR54 gene as a regulator of puberty. N. Engl. J. Med. 349, 1614–1627 (2003)

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Authors and Affiliations

  1. Faculty of Health Science, Bukkyo University, Kyoto, Japan

    Hitoshi Ozawa

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  1. Hitoshi Ozawa
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Correspondence to Hitoshi Ozawa.

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The author declares no competing interests.

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Ozawa, H. Masterful papers that broke open understanding of reproductive neuroendocrinology. Nat Rev Endocrinol 18, 520 (2022). https://doi.org/10.1038/s41574-022-00706-2

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