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NEUROENDOCRINOLOGY

From oxygen sensors to neuroendocrine tumours

Nature Reviews Endocrinology volume 18, page 456 (2022)Cite this article

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How cells regulate their metabolism with respect to oxygen content is an essential problem of biology, linked to angiogenesis and malignancy. Studies by Gregg Semenza identified, purified and cloned hypoxia inducible factor (HIF), which regulates these oxygen-dependent responses. Peter Ratcliffe and William Kaelin’s groups showed that HIF could suppress tumour growth associated with mutations in the von Hippel–Lindau (VHL) tumour suppressor gene and demonstrated that VHL protein (pVHL) regulated both HIFα via a post-translational mechanism and oxygen-sensitive metabolism. The three researchers were awarded the Nobel Prize in Physiology or Medicine in 2019.

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References

Original article

  • Semenza, G. L. et al. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc. Natl Acad. Sci. USA 88, 8725–8729 (1991)

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Related articles

  • Ivan, M. et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464–468 (2001)

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  • Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271–275 (1999)

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  1. University of Medicine & Pharmacy and Laboratory of Molecular, Cellular and Structural Endocrinology, National Institute of Endocrinology, Bucharest, Romania

    Corin Badiu

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  1. Corin Badiu
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Correspondence to Corin Badiu.

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Badiu, C. From oxygen sensors to neuroendocrine tumours. Nat Rev Endocrinol 18, 456 (2022). https://doi.org/10.1038/s41574-022-00699-y

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  • DOI: https://doi.org/10.1038/s41574-022-00699-y

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