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NEUROENDOCRINOLOGY

Functional diversity of corticotropin-releasing hormone

Nature Reviews Endocrinology volume 18, page 333 (2022)Cite this article

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In 1978, Wylie Vale and colleagues isolated corticotropin-releasing hormone (CRH) from sheep hypothalami and published a study of the modulation of stress-induced adrenocorticotropic hormone (ACTH) release by CRH. The study suggested that endogenous CRH has a physiological role in regulating ACTH secretion. In subsequent studies, the Vale team confirmed the peptide sequence of CRH, produced a CRH-specific antibody, identified central CRH receptors (and cloned the subtypes CRHR1 and CRHR2) and identified new family members of the urocortin family (1, 2 and 3). Since these publications, numerous fruitful findings from scientists around the world have supported the hypothesis that CRH from the hypothalamus, via the CRH receptors, controls every cell in the body in terms of maintenance and adaptive responses for homeostasis.

findings from scientists around the world have supported the hypothesis that CRH from the hypothalamus … controls every cell in the body

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References

Original articles

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Authors and Affiliations

  1. Zhejiang University, School of Brain Science and Brain Medicine, Hangzhou, China

    Xue Qun Chen

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  1. Xue Qun Chen
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Correspondence to Xue Qun Chen.

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The author declares no competing interests.

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Chen, X.Q. Functional diversity of corticotropin-releasing hormone. Nat Rev Endocrinol 18, 333 (2022). https://doi.org/10.1038/s41574-022-00663-w

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