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Time-restricted feeding and circadian autophagy for long life


Time-restricted feeding (TRF) has shown many health benefits in different organisms, but its effect on lifespan is unknown. A new study showed that a novel intermittent TRF (iTRF) dietary regimen can extend the healthy lifespan of Drosophila. A clock-dependent nightly rise in autophagy drives the lifespan benefits of iTRF.

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Fig. 1: Health benefits of different forms of TRF in Drosophila.


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S.P. acknowledges the support of grants from the NIH (CA236352, CA258221, AG068550, AG065992), the Wu Tsai Human Performance Alliance and the Joe and Clara Tsai Foundation.

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Correspondence to Satchidananda Panda.

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S.P. is the author of the books The Circadian Code and The Circadian Diabetes Code. H.L. declares no competing interests.

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Long, H., Panda, S. Time-restricted feeding and circadian autophagy for long life. Nat Rev Endocrinol 18, 5–6 (2022).

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