Time-restricted feeding (TRF) has shown many health benefits in different organisms, but its effect on lifespan is unknown. A new study showed that a novel intermittent TRF (iTRF) dietary regimen can extend the healthy lifespan of Drosophila. A clock-dependent nightly rise in autophagy drives the lifespan benefits of iTRF.
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S.P. acknowledges the support of grants from the NIH (CA236352, CA258221, AG068550, AG065992), the Wu Tsai Human Performance Alliance and the Joe and Clara Tsai Foundation.
S.P. is the author of the books The Circadian Code and The Circadian Diabetes Code. H.L. declares no competing interests.
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Long, H., Panda, S. Time-restricted feeding and circadian autophagy for long life. Nat Rev Endocrinol 18, 5–6 (2022). https://doi.org/10.1038/s41574-021-00600-3