The investigation of age-induced disease progression in humans is time consuming and resource intensive. One burning question for the exploration of human metabolic ageing is how similar metabolic changes over a lifetime are between humans and mice. A recent study highlights similarities and disparities between these species throughout their lifespan.
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References
Zhou, Z. et al. Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants. Diabetologia 9, 1963–1972 (2021).
Wagner, R. et al. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat. Med. 27, 49–57 (2021).
Drucker, D. J. Never waste a good crisis: confronting reproducibility in translational research. Cell Metab. 24, 348–360 (2016).
Burd, C. E. et al. Barriers to the preclinical development of therapeutics that target aging mechanisms. J. Gerontol. A Biol. Sci. Med. Sci. 71, 1388–1394 (2016).
Palliyaguru, D. L. et al. Study of longitudinal aging in mice: presentation of experimental techniques. J. Gerontol. A Biol. Sci. Med. Sci. 76, 552–560 (2021).
Palliyaguru, D. L. et al. Fasting blood glucose as a predictor of mortality: lost in translation. Cell Metab. https://doi.org/10.1016/j.cmet.2021.08.013 (2021).
Churchill, G. A., Gatti, D. M., Munger, S. C. & Svenson, K. L. The diversity outbred mouse population. Mamm. Genome 23, 713–718 (2012).
Centers for Disease Control and Prevention. About the National Health and Nutrition Examination Survey https://www.cdc.gov/nchs/nhanes/about_nhanes.htm (2017).
Alquier, T. & Poitout, V. Considerations and guidelines for mouse metabolic phenotyping in diabetes research. Diabetologia 61, 526–538 (2018).
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Hofmann, S.M., Landgraf, R. Research in metabolic ageing — a tale of mice versus humans?. Nat Rev Endocrinol 18, 7–8 (2022). https://doi.org/10.1038/s41574-021-00597-9
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DOI: https://doi.org/10.1038/s41574-021-00597-9
