The effects of the gut microbiota on human health are tremendous. Now, a study on the microbiota of wild mice sheds light on how the microorganisms that inhabit the gut between birth and weaning determine resistance to weight gain during adulthood.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Olszak, T. et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336, 489 (2012).
Cox, L. M. et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158, 705–721 (2014).
Hild, B. et al. Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity. Nat. Metab. 3, 1042–1057 (2021).
Rosshart, S. P. et al. Wild mouse gut microbiota promotes host fitness and improves disease resistance. Cell 171, 1015–1028.e13 (2017).
Vuong, H. E. et al. The maternal microbiome modulates fetal neurodevelopment in mice. Nature 586, 281–286 (2020).
Wibowo, M. C. et al. Reconstruction of ancient microbial genomes from the human gut. Nature 594, 234–239 (2021).
Negron, S. G., Ercan-Sencicek, A. G., Freed, J., Walters, M. & Lin, Z. Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice. Sci. Rep. 10, 20335 (2020).
Suárez-Zamorano, N. et al. Microbiota depletion promotes browning of white adipose tissue and reduces obesity. Nat. Med. 21, 1497–1501 (2015).
Robertson, S. J. et al. Comparison of co-housing and littermate methods for microbiota standardization in mouse models. Cell Rep. 27, 1910–1919.e2 (2019).
Sonnenburg, E. D. & Sonnenburg, J. L. The ancestral and industrialized gut microbiota and implications for human health. Nat. Rev. Microbiol. 17, 383–390 (2019).
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Le Roy, T., Clément, K. Into the wild: early time-window for wild microbes to confer resistance to obesity. Nat Rev Endocrinol 17, 711–712 (2021). https://doi.org/10.1038/s41574-021-00580-4