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Into the wild: early time-window for wild microbes to confer resistance to obesity

The effects of the gut microbiota on human health are tremendous. Now, a study on the microbiota of wild mice sheds light on how the microorganisms that inhabit the gut between birth and weaning determine resistance to weight gain during adulthood.

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  1. Olszak, T. et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336, 489 (2012).

    Article  CAS  Google Scholar 

  2. Cox, L. M. et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158, 705–721 (2014).

    Article  CAS  Google Scholar 

  3. Hild, B. et al. Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity. Nat. Metab. 3, 1042–1057 (2021).

    Article  CAS  Google Scholar 

  4. Rosshart, S. P. et al. Wild mouse gut microbiota promotes host fitness and improves disease resistance. Cell 171, 1015–1028.e13 (2017).

    Article  CAS  Google Scholar 

  5. Vuong, H. E. et al. The maternal microbiome modulates fetal neurodevelopment in mice. Nature 586, 281–286 (2020).

    Article  CAS  Google Scholar 

  6. Wibowo, M. C. et al. Reconstruction of ancient microbial genomes from the human gut. Nature 594, 234–239 (2021).

    Article  CAS  Google Scholar 

  7. Negron, S. G., Ercan-Sencicek, A. G., Freed, J., Walters, M. & Lin, Z. Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice. Sci. Rep. 10, 20335 (2020).

    Article  CAS  Google Scholar 

  8. Suárez-Zamorano, N. et al. Microbiota depletion promotes browning of white adipose tissue and reduces obesity. Nat. Med. 21, 1497–1501 (2015).

    Article  Google Scholar 

  9. Robertson, S. J. et al. Comparison of co-housing and littermate methods for microbiota standardization in mouse models. Cell Rep. 27, 1910–1919.e2 (2019).

    Article  CAS  Google Scholar 

  10. Sonnenburg, E. D. & Sonnenburg, J. L. The ancestral and industrialized gut microbiota and implications for human health. Nat. Rev. Microbiol. 17, 383–390 (2019).

    Article  CAS  Google Scholar 

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Correspondence to Karine Clément.

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Le Roy, T., Clément, K. Into the wild: early time-window for wild microbes to confer resistance to obesity. Nat Rev Endocrinol 17, 711–712 (2021).

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