Up to one in four women with type 1 diabetes mellitus (T1DM) also have polycystic ovary syndrome (PCOS). Under subcutaneous insulin administration, systemic hyperinsulinism might trigger PCOS in women predisposed to the condition. However, very little is known about the long-term consequences of androgen excess in women with T1DM, and management guidelines are lacking.
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The authors acknowledge the support of grants PIE1600050, PI1801122 and PI2100116 from Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III is cofinanced by the European Development Regional Fund ‘A way to achieve Europe’. CIBERDEM and IRYCIS are also initiatives of Instituto de Salud Carlos III.
The authors declare no competing interests.
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Escobar-Morreale, H.F., Bayona, A., Nattero-Chávez, L. et al. Type 1 diabetes mellitus and polycystic ovary syndrome. Nat Rev Endocrinol 17, 701–702 (2021). https://doi.org/10.1038/s41574-021-00576-0