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Type 1 diabetes mellitus and polycystic ovary syndrome

Up to one in four women with type 1 diabetes mellitus (T1DM) also have polycystic ovary syndrome (PCOS). Under subcutaneous insulin administration, systemic hyperinsulinism might trigger PCOS in women predisposed to the condition. However, very little is known about the long-term consequences of androgen excess in women with T1DM, and management guidelines are lacking.

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References

  1. 1.

    Escobar-Morreale, H. F. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat. Rev. Endocrinol. 14, 270–284 (2018).

    Article  Google Scholar 

  2. 2.

    Escobar-Morreale, H. F. et al. High prevalence of the polycystic ovary syndrome and hirsutism in women with type 1 diabetes mellitus. J. Clin. Endocrinol. Metab. 85, 4182–4187 (2000).

    CAS  PubMed  Google Scholar 

  3. 3.

    Asuncion, M. et al. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J. Clin. Endocrinol. Metab. 85, 2434–2438 (2000).

    CAS  PubMed  Google Scholar 

  4. 4.

    Roldan, B. et al. Identification of the source of androgen excess in hyperandrogenic type 1 diabetic patients. Diabetes Care 24, 1297–1299 (2001).

    CAS  Article  Google Scholar 

  5. 5.

    Escobar-Morreale, H. F. & Roldán-Martín, M. B. Type 1 diabetes and polycystic ovary syndrome: systematic review and meta-analysis. Diabetes Care 39, 639–648 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Yildiz, B. O., Bozdag, G., Yapici, Z., Esinler, I. & Yarali, H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum. Reprod. 27, 3067–3073 (2012).

    Article  Google Scholar 

  7. 7.

    Dunaif, A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev. 18, 774–800 (1997).

    CAS  PubMed  Google Scholar 

  8. 8.

    Escobar-Morreale, H. F. et al. Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS. Clin. Chem. 58, 999–1009 (2012).

    CAS  Article  Google Scholar 

  9. 9.

    Pozzilli, P. & Buzzetti, R. A new expression of diabetes: double diabetes. Trends Endocrinol. Metab. 18, 52–57 (2007).

    CAS  Article  Google Scholar 

  10. 10.

    Xu, G. et al. Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study. BMJ 362, k1497 (2018).

    Article  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the support of grants PIE1600050, PI1801122 and PI2100116 from Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III is cofinanced by the European Development Regional Fund ‘A way to achieve Europe’. CIBERDEM and IRYCIS are also initiatives of Instituto de Salud Carlos III.

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Correspondence to Héctor F. Escobar-Morreale.

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The Accu-Chek DiaPort system: https://www.accu-chek.de/de/diaport/index.html

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Escobar-Morreale, H.F., Bayona, A., Nattero-Chávez, L. et al. Type 1 diabetes mellitus and polycystic ovary syndrome. Nat Rev Endocrinol 17, 701–702 (2021). https://doi.org/10.1038/s41574-021-00576-0

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