Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) pathogenesis. However, human islet studies have revealed few consistent molecular changes in T2DM, owing partly to technical and biological confounding factors. A new multi-omics study of islets from well-phenotyped living donors attempts to overcome these limitations to catalogue T2DM-associated molecular changes.
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The authors thank M. Wortham and H. Zhu for comments. Work in the Sander laboratory is supported by grants from the National Institutes of Health R01DK078803, R01DK068471, R01DK114427, R01DK122607, U01DK120429 and UG3DK122639.
The authors declare no competing interests.
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Wang, G., Sander, M. A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus. Nat Rev Endocrinol 17, 641–642 (2021). https://doi.org/10.1038/s41574-021-00556-4