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TIM4+ adipose tissue-resident macrophages: new modulators of adiposity

Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4+ resident ATMs, modulate adipocyte size via platelet-derived growth factor-CC production during development and diet-induced adipose tissue expansion.

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Fig. 1: Distinct roles of adipose tissue macrophages.

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  1. Kim, J. I. et al. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol. Cell Biol. 35, 1686–1699 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I. & Kim, J. B. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front. Endocrinol. 7, 30 (2016).

    Article  Google Scholar 

  3. Lee, Y. S., Wollam, J. & Olefsky, J. M. An integrated view of immunometabolism. Cell 172, 22–40 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ito, A. et al. Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J. Biol. Chem. 283, 35715–35723 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Weisberg, S. P. et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Invest. 116, 115–124 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Cox, N. et al. Diet-regulated production of PDGFcc by macrophages controls energy storage. Science 373, eabe9383 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Sun, C. et al. Mosaic mutant analysis identifies PDGFRalpha/PDGFRbeta as negative regulators of adipogenesis. Cell Stem Cell 26, 707–721 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Cao, Y. Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity. Cell Metab. 18, 478–489 (2013).

    Article  CAS  PubMed  Google Scholar 

  9. Cao, R. et al. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors. FASEB J. 16, 1575–1583 (2002).

    Article  CAS  PubMed  Google Scholar 

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The authors acknowledge the support of a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT; NRF-2020R1A3B2078617 to J.B.K., NRF-2021R1C1C2010446 to J.Y.H.).

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Correspondence to Jae Bum Kim.

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Huh, J.Y., Kim, J.B. TIM4+ adipose tissue-resident macrophages: new modulators of adiposity. Nat Rev Endocrinol 17, 645–646 (2021).

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