Harnessing the thermogenic, energy-expending capacity of adipocytes has the potential to combat metabolic disorders. Although β3-adrenergic receptor agonists are the best-known activators of thermogenesis, they carry considerable cardiovascular risks. A new study demonstrates the ability of G protein-coupled receptor 3 to intrinsically drive adipose thermogenesis independent of β3-adrenergic receptor signalling.
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The authors declare no competing interests.
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Auger, C., Kajimura, S. Detouring adrenergic stimulation to induce adipose thermogenesis. Nat Rev Endocrinol 17, 579–580 (2021). https://doi.org/10.1038/s41574-021-00546-6