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Detouring adrenergic stimulation to induce adipose thermogenesis

Nature Reviews Endocrinology volume 17, pages 579–580 (2021)Cite this article

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Harnessing the thermogenic, energy-expending capacity of adipocytes has the potential to combat metabolic disorders. Although β3-adrenergic receptor agonists are the best-known activators of thermogenesis, they carry considerable cardiovascular risks. A new study demonstrates the ability of G protein-coupled receptor 3 to intrinsically drive adipose thermogenesis independent of β3-adrenergic receptor signalling.

Refers to Sveidahl Johansen, O. et al. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell https://doi.org/10.1016/j.cell.2021.04.037 (2021).

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Fig. 1: An alternative paradigm for the activation of adipose thermogenesis.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Christopher Auger & Shingo Kajimura

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  1. Christopher Auger
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  2. Shingo Kajimura
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Correspondence to Shingo Kajimura.

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The authors declare no competing interests.

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Auger, C., Kajimura, S. Detouring adrenergic stimulation to induce adipose thermogenesis. Nat Rev Endocrinol 17, 579–580 (2021). https://doi.org/10.1038/s41574-021-00546-6

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