A new study has reported genetic evidence that MEK–ERK signalling is needed by β-cells, both for maintenance of β-cell mass and for optimization of insulin release. Their results point towards a new challenge of disentangling ERK signalling across multiple time scales.
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Acknowledgements
Research in the lab of M.O.H. is supported by grants from the NIH (NIDDK-110276), JDRF (2-SRA-2021-1054-M-N) and ADA (1-19-IBS-078). Research in the lab of J.G.A. is supported by grants from the NIH (NIGMS-GM115650). Both authors are indebted to the talented trainees who have entrusted them with the responsibility of their mentorship over the years.
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Huising, M.O., Albeck, J.G. Temporal coding of ERK signalling in β-cells. Nat Rev Endocrinol 17, 517–518 (2021). https://doi.org/10.1038/s41574-021-00527-9
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DOI: https://doi.org/10.1038/s41574-021-00527-9
