REPRODUCTIVE ENDOCRINOLGY

Towards subtypes — deep endometriosis oestrogen receptor-α expression

Most research treats endometriosis as a single entity, potentially obscuring informative subtype-specific associations with risk factors, biomarkers and treatment responses. A 2020 study raises the hypothesis that deep endometriosis oestrogen receptor-α expression might be associated with progestin treatment and the degree of post-surgical excision pain.

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Acknowledgements

The authors acknowledge the support of Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) grants R01 HD094842 and R21 HD096358.

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Correspondence to Amy L. Shafrir.

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S.M. serves as an advisory board member for AbbVie and served as a working group member for Roche. A.S. and S.M. receive funding support from the J. Willard and Alice S. Marriott and the Marriott Daughters’ Foundations – all unrelated to this work.

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Shafrir, A.L., Missmer, S.A. Towards subtypes — deep endometriosis oestrogen receptor-α expression. Nat Rev Endocrinol 16, 541–542 (2020). https://doi.org/10.1038/s41574-020-0394-0

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