Most research treats endometriosis as a single entity, potentially obscuring informative subtype-specific associations with risk factors, biomarkers and treatment responses. A 2020 study raises the hypothesis that deep endometriosis oestrogen receptor-α expression might be associated with progestin treatment and the degree of post-surgical excision pain.
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The authors acknowledge the support of Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) grants R01 HD094842 and R21 HD096358.
S.M. serves as an advisory board member for AbbVie and served as a working group member for Roche. A.S. and S.M. receive funding support from the J. Willard and Alice S. Marriott and the Marriott Daughters’ Foundations – all unrelated to this work.
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Shafrir, A.L., Missmer, S.A. Towards subtypes — deep endometriosis oestrogen receptor-α expression. Nat Rev Endocrinol 16, 541–542 (2020). https://doi.org/10.1038/s41574-020-0394-0