For type 1 diabetes mellitus (T1DM), keeping glucose levels within the normal range of 65â150âmg/dl with administered insulin has had limited success. Now, Fussenegger and colleagues have engineered cells to release insulin in response to electrical signals, but can this advance lead to better glucose control?
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References
Ashcroft, F. M. & Rorsman, P. K(ATP) channels and islet hormone secretion: new insights and controversies. Nat. Rev. Endocrinol. 9, 660â669 (2013).
Brown, S. A. et al. Six-month randomized, multicenter trial of closed-loop control in type 1 diabetes. N. Engl. J. Med. 381, 1707â1717 (2019).
Vantyghem, M. C., de Koning, E. J. P., Pattou, F. & Rickels, M. R. Advances in beta-cell replacement therapy for the treatment of type 1 diabetes. Lancet 394, 1274â1285 (2019).
Veres, A. et al. Charting cellular identity during human in vitro β-cell differentiation. Nature 569, 368â373 (2019).
Krawczyk, K. et al. Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice. Science 368, 993â1001 (2020).
Cryer, P. E. The barrier of hypoglycemia in diabetes. Diabetes 57, 3169â3176 (2008).
Evron, Y. et al. Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply. Sci. Rep. 8, 6508 (2018).
Hwa, A. J. & Weir, G. C. Transplantation of macroencapsulated insulin-producing cells. Curr. Diab. Rep. 18, 50 (2018).
Omer, A. et al. Exercise induces hypoglycemia in rats with islet transplantation. Diabetes 53, 360â365 (2004).
Acknowledgements
The author has been supported by grants from the NIH (R01 DK110390 and P30 DK036836 Joslin Diabetes Research Center [DRC]), the Juvenile Diabetes Research Foundation and the Diabetes Research and Wellness Foundation. Valuable advice was provided by S. Bonner-Weir.
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Weir, G.C. A novel cellular engineering approach to diabetes mellitus. Nat Rev Endocrinol 16, 477â478 (2020). https://doi.org/10.1038/s41574-020-0389-x
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DOI: https://doi.org/10.1038/s41574-020-0389-x