Vitamin D supplementation: a novel therapy for aldosteronism?

Available evidence demonstrates a crosstalk between the renin–angiotensin and the parathyroid hormone–vitamin D systems. A new study suggests that vitamin D supplementation can lower systolic blood pressure and plasma aldosterone levels in patients with primary aldosteronism.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Model of how vitamin D deficiency or insufficiency could lead to secondary hyperparathyroidism.


  1. 1.

    Ismail, N. A., Kamaruddin, N. A., Azhar Shah, S. & Sukor, N. The effect of vitamin D treatment on clinical and biochemical outcomes of primary aldosteronism. Clin. Endocrinol. (2020).

    Article  Google Scholar 

  2. 2.

    Rossi, G. P. Primary aldosteronism: JACC State-of-the-Art Review. J. Am. Coll. Cardiol. 74, 2799–2811 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Gao, X. et al. The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant “neoplastic” steroidogenesis in adrenals. J. Steroid Biochem. Mol. Biol. 193, 105434 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Mazzocchi, G., Aragona, F., Malendowicz, L. K. & Nussdorfer, G. G. PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells. Am. J. Physiol. Metab. 280, E209–E213 (2001).

    CAS  Google Scholar 

  5. 5.

    Chhokar, V. S. et al. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation 111, 871–878 (2005).

    CAS  Article  Google Scholar 

  6. 6.

    Maniero, C. et al. Primary hyperparathyroidism with concurrent primary aldosteronism. Hypertension 58, 341–346 (2011).

    CAS  Article  Google Scholar 

  7. 7.

    Maniero, C. et al. Mild hyperparathyroidism: a novel surgically correctable feature of primary aldosteronism. J. Hypertens. 30, 390–395 (2012).

    CAS  Article  Google Scholar 

  8. 8.

    Rossi, G. P. et al. Hyperparathyroidism can be useful in the identification of primary aldosteronism due to aldosterone-producing adenoma. Hypertension 60, 431–436 (2012).

    CAS  Article  Google Scholar 

  9. 9.

    Lenzini, L. et al. PTH modulation by aldosterone and angiotensin II is blunted in hyperaldosteronism and rescued by adrenalectomy. J. Clin. Endocrinol. Metab 104, 3726–3734 (2019).

    Article  Google Scholar 

  10. 10.

    Holick, M. F. et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 96, 1911–1930 (2011).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Gian Paolo Rossi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rossi, G.P., Lenzini, L. Vitamin D supplementation: a novel therapy for aldosteronism?. Nat Rev Endocrinol 16, 303–304 (2020).

Download citation

Further reading


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing