Human sperm RNA code senses dietary sugar

A new study reveals that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these changes are associated with changes in sperm motility. This rapid response by sperm to nutritional fluctuation raises intriguing questions regarding the underlying mechanisms and the potential effects on offspring metabolic health.

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Fig. 1: Potential modulation of sperm by high-sugar diet.


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The authors thank Xudong Zhang for discussion. Y.Z. is supported by MOST (2019YFA0802600 and 2018YFC1004500) and Q.C. is supported by NIH (R01HD092431).

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Correspondence to Ying Zhang or Qi Chen.

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The authors declare no competing interests.

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Zhang, Y., Chen, Q. Human sperm RNA code senses dietary sugar. Nat Rev Endocrinol 16, 200–201 (2020). https://doi.org/10.1038/s41574-020-0331-2

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