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Recognizing hypoxia in phaeochromocytomas and paragangliomas

Studies uncovering the cellular mechanisms of adaptation to varying oxygen levels were recognized with the 2019 Nobel Prize in Physiology or Medicine. Here, we focus on the remarkable parallels between the pathways regulating oxygen availability and those driving rare neuroendocrine tumours, phaeochromocytomas and paragangliomas, and discuss the translational implications of this connection.

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P.L.M.D. is the Charles Tucker Hayes Chair in Oncology and is supported by the NIH (GM114102), Alex’s Lemonade Stand Foundation for Childhood Cancer Innovation Award (co-funded by Flashes of Hope and Northwest Mutual) and National Center for Advancing Translational Sciences (UL1 TR002645). R.A.T. holds a Miguel Servet-I research contract by Institute of Health Carlos III (ISCIII) of the Ministry of Economy (CP17/00199) and Competitiveness; is supported by an Olga Torres Foundation emerging researcher grant and by the Swiss Bridge Award for cancer immunotherapy research; and received a research grant from Novartis.

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Correspondence to Patricia L. M. Dahia or Rodrigo A. Toledo.

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The authors declare no competing interests.

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Dahia, P.L.M., Toledo, R.A. Recognizing hypoxia in phaeochromocytomas and paragangliomas. Nat Rev Endocrinol 16, 191–192 (2020).

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