A mitochondrial root to accelerated ageing and frailty

A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.

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Fig. 1: Proposed mechanisms of mitochondrial dysfunction in individuals with frailty.


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The authors acknowledge the support of the Intramural Research Program of the National Institute on Aging.

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Correspondence to Luigi Ferrucci.

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The authors declare no competing interests.

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Ferrucci, L., Zampino, M. A mitochondrial root to accelerated ageing and frailty. Nat Rev Endocrinol 16, 133–134 (2020).

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