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ISLET BIOLOGY

Transplantation of stem cell-derived pancreatic islet cells

A large fraction of patients with diabetes mellitus require insulin treatment to control glucose metabolism; however, this treatment brings risks of hypoglycaemia and provides suboptimal metabolic control. Transplantation of stem cell-derived pancreatic islet cells could be an ideal solution, which is approaching clinical translation.

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References

  1. National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes in America 3rd ed (NIH, 2018).

  2. Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L. & Millman, J. R. Single-cell transcriptome profiling reveals beta cell maturation in stem cell-derived islets after transplantation. Cell Rep. 32, 108067 (2020).

    CAS  Article  Google Scholar 

  3. Ricordi, C. et al. National Institutes of Health-sponsored clinical islet transplantation consortium phase 3 trial: manufacture of a complex cellular product at eight processing facilities. Diabetes 65, 3418–3428 (2016).

    CAS  Article  Google Scholar 

  4. Lablanche, S. et al. Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol. 6, 527–537 (2018).

    CAS  Article  Google Scholar 

  5. Ricordi, C. et al. Transplanting islet cells can fix brittle diabetes. Why isn’t it available in the U.S.? CellR4 7, e2768 (2019).

    Google Scholar 

  6. D’Amour, K. A. et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24, 1392–1401 (2006).

    Article  Google Scholar 

  7. Pagliuca, F. W. et al. Generation of functional human pancreatic beta cells in vitro. Cell 159, 428–439 (2014).

    CAS  Article  Google Scholar 

  8. Velazco-Cruz, L. et al. Acquisition of dynamic function in human stem cell-derived beta cells. Stem Cell Reports 12, 351–365 (2019).

    CAS  Article  Google Scholar 

  9. Agulnick, A. D. et al. Insulin-producing endocrine cells differentiated in vitro from human embryonic stem cells function in macroencapsulation devices in vivo. Stem Cells Transl Med. 4, 1214–1222 (2015).

    CAS  Article  Google Scholar 

  10. Millman, J. R. et al. Generation of stem cell-derived beta-cells from patients with type 1 diabetes. Nat. Commun. 7, 11463 (2016).

    CAS  Article  Google Scholar 

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Correspondence to Camillo Ricordi.

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Lanzoni, G., Ricordi, C. Transplantation of stem cell-derived pancreatic islet cells. Nat Rev Endocrinol 17, 7–8 (2021). https://doi.org/10.1038/s41574-020-00430-9

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  • DOI: https://doi.org/10.1038/s41574-020-00430-9

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