EXERCISE

Aerobics — decades of data for future hypothesis-testing research

Typically, our mechanistic understanding about links between exercise and mortality come from epidemiological and short-period training studies. An initial transcriptomic study shows that decades-long endurance training shifts skeletal muscle gene activity to favour cellular respiration, upholding the consilience of evidence for ‘aerobic’ as a central feature of health and longevity.

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References

  1. 1.

    Cooper, K. H. The history of aerobics (50 years and still counting). Res. Q. Exerc. Sport 89, 129–134 (2018).

    Article  Google Scholar 

  2. 2.

    Blair, S. N. et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 276, 205–210 (1996).

    CAS  Article  Google Scholar 

  3. 3.

    Myers, J. et al. Exercise capacity and mortality among men referred for exercise testing. N. Engl. J. Med. 346, 793–801 (2002).

    Article  Google Scholar 

  4. 4.

    Mandsager, K. et al. Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing. JAMA Netw. Open 1, e183605 (2018).

    Article  Google Scholar 

  5. 5.

    Wilson, E. O. Consilience among the great branches of learning. Daedalus 127, 131–149 (1998).

    CAS  PubMed  Google Scholar 

  6. 6.

    MacDonald, T. L. et al. Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise. Nat. Metab. https://doi.org/10.1038/s42255-020-0240-7 (2020).

    Article  PubMed  Google Scholar 

  7. 7.

    Sanford, J. A. et al. Molecular transducers of physical activity consortium (MoTrPAC): mapping the dynamic responses to exercise. Cell 181, 1464–1474 (2020).

    CAS  Article  Google Scholar 

  8. 8.

    Chapman, M. A. et al. Skeletal muscle transcriptomic comparison between long-term trained and untrained men and women. Cell Rep. 31, 107808 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Koch, L. G. & Britton, S. L. Theoretical and biological evaluation of the link between low exercise capacity and disease risk. Cold Spring Harb. Perspect. Med. 8, a029868 (2018).

    Article  Google Scholar 

  10. 10.

    Koch, L. G. et al. Intrinsic aerobic capacity sets a divide for aging and longevity. Circ. Res. 109, 1162–1172 (2011).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Lauren Gerard Koch.

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Koch, L.G., Britton, S.L. Aerobics — decades of data for future hypothesis-testing research. Nat Rev Endocrinol 16, 627–628 (2020). https://doi.org/10.1038/s41574-020-00415-8

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