Typically, our mechanistic understanding about links between exercise and mortality come from epidemiological and short-period training studies. An initial transcriptomic study shows that decades-long endurance training shifts skeletal muscle gene activity to favour cellular respiration, upholding the consilience of evidence for ‘aerobic’ as a central feature of health and longevity.
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Koch, L.G., Britton, S.L. Aerobics — decades of data for future hypothesis-testing research. Nat Rev Endocrinol 16, 627–628 (2020). https://doi.org/10.1038/s41574-020-00415-8
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DOI: https://doi.org/10.1038/s41574-020-00415-8
