Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM

Islet inflammation (insulitis) in type 1 diabetes mellitus is triggered by a deleterious dialogue between β-cells and the immune system, inducing β-cell dysfunction and death. This concept, outlined in our 2009 Review, has been confirmed and extended. Here, we provide a brief update of the field and outline key pending questions.

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Fig. 1: An updated view of the dialogue between β-cells and the immune system.

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Acknowledgements

The authors acknowledge the support of grants from the JDRF (2-SRA-2019-834-S-B); Welbio and Fonds National de la Recherche Scientifique (FNRS), Belgium, grants CR-2015A-06 and CR-2019C-04; Innovate2CureType1-Dutch Diabetes Research Fundation (DDRF); and start-up funding provided by the Indiana Biosciences Research Institute. D.L.E. has also received funding from the Innovative Medicines Initiative Joint Undertaking under grant agreements nos 115797 and 945268 (INNODIA and INNODIA HARVEST). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and “EFPIA”, “JDRF” and “The Leona M. and Harry B. Helmsley Charitable Trust”.

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Correspondence to Decio L. Eizirik or Maikel L. Colli.

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Eizirik, D.L., Colli, M.L. Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM. Nat Rev Endocrinol 16, 611–612 (2020). https://doi.org/10.1038/s41574-020-00409-6

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