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Can microbes increase exercise performance in athletes?

Faecal microbiota transplantation (FMT) has been suggested to be a therapeutic strategy for inflammatory diseases and it is known that regular physical activity can alter the composition of the gut microbiota. Now, a study proposes that FMT might increase exercise performance in athletes, raising the possibility of ‘faecal doping’.

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  1. Whitham, M. & Febbraio, M. A. The ever-expanding myokinome: discovery challenges and therapeutic implications. Nat. Rev. Drug Discov. 15, 719–729 (2016).

    Article  CAS  Google Scholar 

  2. Sonnenburg, J. L. & Backhed, F. Diet-microbiota interactions as moderators of human metabolism. Nature 535, 56–64 (2016).

    Article  CAS  Google Scholar 

  3. Imdad, A. et al. Fecal transplantation for treatment of inflammatory bowel disease. Cochrane Database Syst. Rev. 11, CD012774 (2018).

    PubMed  Google Scholar 

  4. Scheiman, J. et al. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat. Med. 25, 1104–1109 (2019).

    Article  CAS  Google Scholar 

  5. Mailing, L. J., Allen, J. M., Buford, T. W., Fields, C. J. & Woods, J. A. Exercise and the gut microbiome: a review of the evidence, potential mechanisms, and implications for human health. Exerc. Sport Sci. Rev. 47, 75–85 (2019).

    Article  Google Scholar 

  6. Marlicz, W. & Loniewski, I. The effect of exercise and diet on gut microbial diversity. Gut 64, 519–520 (2015).

    Article  CAS  Google Scholar 

  7. Farrell, P. A., Wilmore, J. H., Coyle, E. F., Billing, J. E. & Costill, D. L. Plasma lactate accumulation and distance running performance. Med. Sci. Sports. 11, 338–344 (1979).

    CAS  PubMed  Google Scholar 

  8. Newman, E. V. D. D. B., Edwards, H. T. & Webstter, F. A. The rate of lactic acid removal in exercise. Am. J. Physiol. 118, 457–462 (1937).

    Article  CAS  Google Scholar 

  9. Starkie, R. L., Rolland, J., Angus, D. J., Anderson, M. J. & Febbraio, M. A. Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running. Am. J. Physiol. Cell Physiol. 280, C769–774 (2001).

    Article  CAS  Google Scholar 

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Correspondence to Mark A. Febbraio.

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Turpin-Nolan, S.M., Joyner, M.J. & Febbraio, M.A. Can microbes increase exercise performance in athletes?. Nat Rev Endocrinol 15, 629–630 (2019).

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