A large registry-based study found that maternal overweight and obesity are associated with incident type 2 diabetes mellitus in offspring. The results align with those of prospective cohort studies and emphasize a need for interventions that target maternal weight during very early gestation, to optimize maternal and offspring health.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Flegal, K. M., Carroll, M. D., Kit, B. K. & Ogden, C. L. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA 307, 491–497 (2012).
March of Dimes. Obesity among women of childbearing age United States, 2007–2017. March of Dimes https://www.marchofdimes.org/Peristats/ViewSubtopic.aspx?reg=99&top=17&stop=350&lev=1&slev=1&obj=1 (2019).
Oken, E. & Gillman, M. W. Fetal origins of obesity. Obes. Res. 11, 496–506 (2003).
Dabelea, D. & Crume, T. Maternal environment and the transgenerational cycle of obesity and diabetes. Diabetes 60, 1849–1855 (2011).
Lahti-Pulkkinen, M. et al. Consequences of being overweight or obese during pregnancy on diabetes in the offspring: a record linkage study in Aberdeen. Scotland. Diabetologia https://doi.org/10.1007/s00125-019-4891 (2019).
Hivert, M. F., Rifas-Shiman, S. L., Gillman, M. W. & Oken, E. Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood. Obesity 24, 1546–1553 (2016).
Arslanian, S. et al. Evaluation and management of youth-onset type 2 diabetes: a position statement by the American Diabetes Association. Diabetes Care 41, 2648–2668 (2018).
Perng, W., Oken, E. & Dabelea, D. Developmental overnutrition and offspring obesity and type 2 diabetes. Diabetologia https://doi.org/10.1007/s00125-019-4914-1 (in press).
The RISE Consortium. Impact of insulin and metformin versus metformin alone on beta-cell function in youth with impaired glucose tolerance or recently diagnosed type 2 diabetes. Diabetes Care 41, 1717–1725 (2018).
Dodd, J. M., Grivell, R. M., Crowther, C. A. & Robinson, J. S. Antenatal interventions for overweight or obese pregnant women: a systematic review of randomised trials. BJOG 117, 1316–1326 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Perng, W., Oken, E. Maternal obesity and associated offspring diabetes mellitus. Nat Rev Endocrinol 15, 630–632 (2019). https://doi.org/10.1038/s41574-019-0249-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41574-019-0249-8