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Treating T2DM and obesity with bariatric surgery and GLP1 agents

Bariatric surgery often produces remission of hyperglycaemia in patients with coexistent obesity and type 2 diabetes mellitus, but the hyperglycaemia is prone to return years later. A prospective study demonstrates that therapy with a glucagon-like peptide 1 receptor agonist can reinstate normal glycaemic control in many of these patients.

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  1. 1.

    Rubino, F. et al. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Diabetes Care. 39, 861–877 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Schauer, P. R. et al. Bariatric surgery versus intensive medical therapy for diabetes — 5-year outcomes. N. Engl. J. Med. 376, 641–651 (2017).

    Article  Google Scholar 

  3. 3.

    Adams, T. D. et al. Weight and metabolic outcomes 12 years after gastric bypass. N. Engl. J. Med. 377, 1143–1155 (2017).

    Article  Google Scholar 

  4. 4.

    Steinert, R. E. et al. Ghrelin, CCK, GLP-1, and PYY(3–36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB. Physiol. Rev. 97, 411–463 (2017).

    Article  Google Scholar 

  5. 5.

    Nannipieri, M. et al. Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones. J. Clin. Endocrinol. Metab. 98, 4391–4399 (2013).

    CAS  Article  Google Scholar 

  6. 6.

    Hutch, C. R. & Sandoval, D. The role of GLP-1 in the metabolic success of bariatric surgery. Endocrinology 158, 4139–4151 (2017).

    Article  Google Scholar 

  7. 7.

    Lim, S., Kim, K. M. & Nauck, M. A. Glucagon-like peptide-1 receptor agonists and cardiovascular events: class effects versus individual patterns. Trends Endocrinol. Metab. 29, 238–248 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Bailey, C. J. & Marx, N. Cardiovascular protection in type 2 diabetes: insights from recent outcome trials. Diabetes Obes. Metab. 21, 3–14 (2019).

    Article  Google Scholar 

  9. 9.

    Gorgojo-Martínez, J. J., Feo-Ortega, G. & Serrano-Moreno, C. Effectiveness and tolerability of liraglutide in patients with type 2 diabetes mellitus and obesity after bariatric surgery. Surg. Obes. Relat. Dis. 12, 1856–1863 (2016).

    Article  Google Scholar 

  10. 10.

    Miras, A. D. et al. Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. (2019).

    Article  PubMed  Google Scholar 

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Correspondence to Clifford J. Bailey.

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Bailey, C.J. Treating T2DM and obesity with bariatric surgery and GLP1 agents. Nat Rev Endocrinol 15, 504–506 (2019).

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