Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberrant hormonal signalling and increased fibrosis in the endometrium and impaired endometrial receptivity.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Immunoreactivity of Plasminogen Activator Inhibitor 1 and Its Correlation with Dysmenorrhea and Lesional Fibrosis in Adenomyosis
Reproductive Sciences Open Access 08 March 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Taylor, H. S. et al. HOX gene expression is altered in the endometrium of women with endometriosis. Hum. Reprod. 14, 1328–1331 (1999).
Wu, Y. et al. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am. J. Obstet. Gynecol. 193, 371–380 (2005).
Kim, J. J. et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol. Hum. Reprod. 13, 323–332 (2007).
Kim, T. H. et al. Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci. Transl Med. 11, eaaf7533 (2019).
Vinatier, D., Cosson, M. & Dufour, P. Is endometriosis an endometrial disease? Eur. J. Obstet. Gynecol. Reprod. Biol. 91, 113–125 (2000).
Guo, S. W. Fibrogenesis resulting from cyclic bleeding: the holy grail of the natural history of ectopic endometrium. Hum. Reprod. 33, 353–356 (2018).
Liu, X. et al. Transvaginal elastosonography as an imaging technique for diagnosing adenomyosis. Reprod. Sci. 25, 498–514 (2018).
Markiewicz, M. et al. A role for estrogen receptor-alpha and estrogen receptor-beta in collagen biosynthesis in mouse skin. J. Invest. Dermatol. 133, 120–127 (2013).
Oie, S. et al. HDAC3 regulates stability of estrogen receptor α mRNA. Biochem. Biophys. Res. Commun. 432, 236–241 (2013).
Hoeksema, M. A. et al. Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol. Med. 6, 1124–1132 (2014).
Acknowledgements
The author acknowledges the support of grants 81530040 and 81771553 from the National Science Foundation of China and an Excellence in Centers of Clinical Medicine grant (2017ZZ01016) from the Science and Technology Commission of Shanghai Municipality.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author is an adjunct professor at the Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA. However, his affiliation at this university plays no part on the views expressed in this commentary. He has nothing else to declare.
Rights and permissions
About this article
Cite this article
Guo, SW. Genesis, genes and epigenetics of endometriosis-associated infertility. Nat Rev Endocrinol 15, 259–260 (2019). https://doi.org/10.1038/s41574-019-0191-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41574-019-0191-9
This article is cited by
-
Skp2 Deteriorates the Uterine Receptivity by Interacting with HOXA10 and Promoting its Degradation
Reproductive Sciences (2021)
-
Immunoreactivity of Plasminogen Activator Inhibitor 1 and Its Correlation with Dysmenorrhea and Lesional Fibrosis in Adenomyosis
Reproductive Sciences (2021)