Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberrant hormonal signalling and increased fibrosis in the endometrium and impaired endometrial receptivity.
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Acknowledgements
The author acknowledges the support of grants 81530040 and 81771553 from the National Science Foundation of China and an Excellence in Centers of Clinical Medicine grant (2017ZZ01016) from the Science and Technology Commission of Shanghai Municipality.
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The author is an adjunct professor at the Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA. However, his affiliation at this university plays no part on the views expressed in this commentary. He has nothing else to declare.
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Guo, SW. Genesis, genes and epigenetics of endometriosis-associated infertility. Nat Rev Endocrinol 15, 259–260 (2019). https://doi.org/10.1038/s41574-019-0191-9
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DOI: https://doi.org/10.1038/s41574-019-0191-9
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