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A healthy lifestyle — reducing T2DM risk in shift workers?

Nature Reviews Endocrinologyvolume 15pages194196 (2019) | Download Citation

A recent study shows that a history of rotating night-shift work and an unhealthy lifestyle are associated with increased risk of type 2 diabetes mellitus (T2DM), both independently and synergistically. This is the first large-scale, prospective study to quantify how a healthy lifestyle might partially offset T2DM risk in shift workers.

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  1. 1.

    Neil-Sztramko, S. et al. Health-related interventions among night shift workers: a critical review of the literature. Scand. J. Work Environ. Health 40, 543–556 (2014).

  2. 2.

    Shan, Z. et al. Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses. BMJ 363, k4641 (2018).

  3. 3.

    Proper, K. I. et al. The relationship between shift work and metabolic risk factors. Am. J. Prev. Med. 50, e147–e157 (2016).

  4. 4.

    Stenvers, D. J. et al. Circadian clocks and insulin resistance. Nat. Rev. Endocrinol. 15, 75–89 (2018).

  5. 5.

    Broussard, J. L. & Van Cauter, E. Disturbances of sleep and circadian rhythms: novel risk factors for obesity. Curr. Opin. Endocrinol. Diabetes Obes. 23, 353–359 (2016).

  6. 6.

    McHill, A. W. & Wright, K. P. Jr. Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease. Obes. Rev. 18 (Suppl. 1), 15–24 (2017).

  7. 7.

    Al Khatib, H. K. et al. Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: a potential strategy for decreasing intake of free sugars? A randomized controlled pilot study. Am. J. Clin. Nutr. 107, 43–53 (2018).

  8. 8.

    Mattson, M. P. et al. Meal frequency and timing in health and disease. Proc. Natl Acad. Sci. USA 111, 16647–16653 (2014).

  9. 9.

    Vetter, C. et al. Mismatch of sleep and work timing and risk of type 2 diabetes. Diabetes Care 38, 1707–1713 (2015).

  10. 10.

    Vetter, C. Circadian disruption: what do we actually mean? Eur. J. Neurosci. (2018).

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Author information


  1. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA

    • Céline Vetter
  2. Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA

    • Frank A. J. L. Scheer
  3. Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA, USA

    • Frank A. J. L. Scheer


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Competing interests

C.V. is a Nurses’ Health Studies investigator. F.A.J.L.S. has received speaker fees from Bayer HealthCare, Kellogg Company, Pfizer, Philips, Sentara Healthcare and Vanda Pharmaceuticals. F.A.J.L.S. and C.V. were supported in part by NIH grant R01DK105072; F.A.J.L.S. was also in part supported by NIH grants R01HL118601, R01DK099512, R01DK102696 and R01HL140574.

Corresponding author

Correspondence to Frank A. J. L. Scheer.

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