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The ‘obesity paradox’ in action with cancer immunotherapy

Nature Reviews Endocrinologyvolume 15pages132133 (2019) | Download Citation

A recent study has shown that obesity and ageing induce T cell dysfunction and an upregulation of programmed cell death 1 (PD-1) on T cells across species, which is partially mediated by leptin. However, the polarization of T cells towards an exhaustive phenotype correlated with improved response rates to anti-PD-1 therapy in the setting of obesity.

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Author information


  1. Cancer Immunology and Immunotherapy Group, Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James’s Hospital, Dublin, Ireland

    • Joanne Lysaght


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The author declares no competing interests.

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Correspondence to Joanne Lysaght.

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