Circadian rhythm research is beginning to show how rhythms sustain health. Genome-wide transcriptome, metabolome and proteome studies have improved our understanding of circadian regulation. This knowledge is leveraged for behavioural interventions that optimize daily rhythms, the timing of drug delivery and the targeting of clock components to prevent or treat chronic diseases.
A reference human circadian transcriptome atlas elucidated tissue-specific circadian regulation1.
A high-fat diet disrupts the temporal coordination of transcripts and metabolites across multiple organs in rodents6.
Time-restricted eating among men at risk of prediabetes improves blood glucose control and reduces blood pressure without causing weight loss7.
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S.P. has written a book “The Circadan Code” for which he is paid royalty.
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Panda, S. The arrival of circadian medicine. Nat Rev Endocrinol 15, 67–69 (2019). https://doi.org/10.1038/s41574-018-0142-x
Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus
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