Circadian rhythm research is beginning to show how rhythms sustain health. Genome-wide transcriptome, metabolome and proteome studies have improved our understanding of circadian regulation. This knowledge is leveraged for behavioural interventions that optimize daily rhythms, the timing of drug delivery and the targeting of clock components to prevent or treat chronic diseases.
A reference human circadian transcriptome atlas elucidated tissue-specific circadian regulation1.
A high-fat diet disrupts the temporal coordination of transcripts and metabolites across multiple organs in rodents6.
Time-restricted eating among men at risk of prediabetes improves blood glucose control and reduces blood pressure without causing weight loss7.
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Sutton, E. F. et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. 27, 1212–1221 (2018).
Hatori, M. et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 15, 848–860 (2012).
Winter, C. et al. Chrono-pharmacological targeting of the CCL2-CCR2 axis ameliorates atherosclerosis. Cell Metab. 28, 175–182 (2018).
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S.P. has written a book “The Circadan Code” for which he is paid royalty.
About this article
Chronobiology in Medicine (2019)
Journal of Agricultural and Food Chemistry (2019)
Nature Reviews Molecular Cell Biology (2019)
Frontiers in Endocrinology (2019)
Scientific Reports (2019)