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How does lorcaserin facilitate weight loss and who will benefit?

Nature Reviews Endocrinology volume 14, pages 692–693 (2018)Cite this article

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Pharmacotherapy for obesity, as an adjunct to targeted behavioural modifications, can facilitate weight loss. Previous serotonergic candidates have been withdrawn owing to undesirable cardiovascular effects. A new study in a large sample of high-risk patients shows lorcaserin treatment leads to no greater increase in cardiovascular problems than placebo — what does this result mean for personalized pharmacotherapy for obesity?

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Authors and Affiliations

  1. Department of Psychological Sciences at the University of Liverpool, Liverpool, UK

    Carl A. Roberts & Jason C. G. Halford

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  1. Carl A. Roberts
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  2. Jason C. G. Halford
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Correspondence to Carl A. Roberts.

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Competing interests

J.C.G.H declares associations with AstraZeneca, American Beverage Association, Bristol-Myers Squibb, Novo Nordisk and Orexigen. C.A.R declares no competing interests.

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Roberts, C.A., Halford, J.C.G. How does lorcaserin facilitate weight loss and who will benefit?. Nat Rev Endocrinol 14, 692–693 (2018). https://doi.org/10.1038/s41574-018-0109-y

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