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  THYROID DISEASE

Antithyroid drugs and congenital malformations

Nature Reviews Endocrinology volume 14, pages 328–329 (2018)Cite this article

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A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the risk of congenital malformations.

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Authors and Affiliations

  1. Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands

    Tim I. M. Korevaar & Robin P. Peeters

Authors
  1. Tim I. M. Korevaar
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  2. Robin P. Peeters
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Correspondence to Tim I. M. Korevaar.

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The authors declare no competing interests.

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Korevaar, T.I.M., Peeters, R.P. Antithyroid drugs and congenital malformations. Nat Rev Endocrinol 14, 328–329 (2018). https://doi.org/10.1038/s41574-018-0012-6

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