Bone stress injuries, including stress fractures, are overuse injuries that lead to substantial morbidity in active individuals. These injuries occur when excessive repetitive loads are introduced to a generally normal skeleton. Although the precise mechanisms for bone stress injuries are not completely understood, the prevailing theory is that an imbalance in bone metabolism favours microdamage accumulation over its removal and replacement with new bone via targeted remodelling. Diagnosis is achieved by a combination of patient history and physical examination, with imaging used for confirmation. Management of bone stress injuries is guided by their location and consequent risk of healing complications. Bone stress injuries at low-risk sites typically heal with activity modification followed by progressive loading and return to activity. Additional treatment approaches include non-weight-bearing immobilization, medications or surgery, but these approaches are usually limited to managing bone stress injuries that occur at high-risk sites. A comprehensive strategy that integrates anatomical, biomechanical and biological risk factors has the potential to improve the understanding of these injuries and aid in their prevention and management.
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S.J.W.: contribution was facilitated by support from the National Institutes of Health (NIH/NIAMS P30 AR072581) and National Basketball Association–General Electric Healthcare Orthopedics and Sports Medicine Collaboration. K.L.P.: the opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the U.S. Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official U.S. Army or Department of Defense endorsement or approval of the products or services of these organizations.
The authors declare no competing interests.
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Nature Reviews Disease Primers thanks M. Baggaley, who co-reviewed with B. Edwards; G. Robertson, who co-reviewed with N. Maffulli; A. Kemper; M. Schaffler; and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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- Stress fractures
Bone stress injuries with radiologically visible sclerosis or fracture line.
- Stress reactions
Bone stress injuries without radiologically visible sclerosis or fracture line.
- Bone stress injury
Focal failure of bone tissue to repeated loading that results in localized pain and/or an increased risk of complete bone fracture to typically tolerable loads.
The amount of force experienced per unit area of tissue when an external force is applied.
The change in the dimensions of bone tissue when stress is applied.
- Material fatigue
The formation and propagation of cracks in a material due to repeated loading.
Microscopic damage in bone tissue, often in the form of small cracks, in response to repeated stress, which stimulates targeted remodelling.
- Targeted remodelling
The coordinated and sequential action of bone-resorbing osteoclasts and bone-forming osteoblasts to remove bone microdamage and replace it with new bone.
- Insufficiency fracture
A bone injury due to loads within the normal range being applied to an abnormal bone or a bone with abnormal biology.
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Hoenig, T., Ackerman, K.E., Beck, B.R. et al. Bone stress injuries. Nat Rev Dis Primers 8, 26 (2022). https://doi.org/10.1038/s41572-022-00352-y
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