COSMIC-313 combines all of the approved drugs against actionable targets in renal cell carcinoma into one triplet regimen. Although this approach has greater clinical efficacy than one of the standard-of-care doublet therapies, toxicities can limit adequate drug administration and, thus, we argue that this regimen should not yet be adopted. We also discuss ongoing investigations of other triplet regimens.
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K.E.B. has received institutional research funding from BMS, Eisai, Exelixis, Pfizer and Merck. K.E.B. has acted as a consultant for BMS and Exelixis. B.I.R. has received institutional research funding and/or has acted as a consultant for BMS, Eisai, Exelixis, Pfizer and Merck.
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Beckermann, K.E., Rini, B.I. A triple dose of optimism: an initial foray into triplet therapy in metastatic renal cell carcinoma. Nat Rev Clin Oncol 20, 581–582 (2023). https://doi.org/10.1038/s41571-023-00795-6