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Haematological cancer

Determinants of response and resistance to T cell-engaging therapies in multiple myeloma

Nature Reviews Clinical Oncology volume 20, pages 505–506 (2023)Cite this article

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Bispecific T cell engagers offer a novel treatment approach for patients with multiple myeloma, although mechanisms of resistance are largely unknown. Here, we discuss the implications of a recent report from Friedrich et al. that highlights the importance of pre-treatment T cell characteristics for a response to the T cell engager elranatamab and how these data might be used to inform future study and trial design.

Refers to Friedrich, M. J. et al. The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients. Cancer Cell https://doi.org/10.1016/j.ccell.2023.02.008 (2023).

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Fig. 1: Immune cell subsets at baseline and in response to BCMA-targeted bispecific T cell-engaging therapies.

References

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Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Jerome Lipper Center for Multiple Myeloma Research, Harvard Medical School, Boston, MA, USA

    Shonali Midha & Kenneth C. Anderson

  2. Division of Hematology, Brigham and Women’s Hospital, Boston, MA, USA

    Shonali Midha & Kenneth C. Anderson

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  1. Shonali Midha
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  2. Kenneth C. Anderson
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Correspondence to Kenneth C. Anderson.

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Competing interests

K.C.A. has acted as a consultant of AstraZeneca, Bristol Myers Squibb and Janssen. S.M. declares no competing interests

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Midha, S., Anderson, K.C. Determinants of response and resistance to T cell-engaging therapies in multiple myeloma. Nat Rev Clin Oncol 20, 505–506 (2023). https://doi.org/10.1038/s41571-023-00775-w

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