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Colorectal cancer

TNT and local recurrence in the RAPIDO trial — untangling the puzzle


Neoadjuvant chemotherapy offers a pragmatic alternative to the difficulties associated with delivering timely adjuvant chemotherapy in rectal cancer. Enthusiasm for administering neoadjuvant therapy to all patients with locally advanced rectal cancer is based on data from several phase III trials. Data from the RAPIDO trial are a critical component of this evidence.

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Fig. 1: Fragmentation of locally advanced rectal cancers following an extended delay between radiotherapy and surgery.


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Correspondence to Robert Glynne-Jones.

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Competing interests

R.G.-J. has acted as an advisor and/or consultant of Amgen and Incyte and has received honoraria for lectures from Servier and Johnson & Johnson. J.H. declares no competing interests.

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Glynne-Jones, R., Hollingshead, J. TNT and local recurrence in the RAPIDO trial — untangling the puzzle. Nat Rev Clin Oncol 20, 357–358 (2023).

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