Plasma cell-free DNA analysis has emerged as a powerful liquid biopsy assay to assess circulating tumour DNA in response to cancer treatments. A new study shows that cell-free DNA can also inform on expansion kinetics and tumour-infiltration patterns in patients receiving chimeric antigen receptor T cells and, together with circulating tumour DNA, provides vivid prognostic insights into intratumoural dynamics.
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M.V.M. is an inventor in patents related to adoptive cell therapies, held by the Massachusetts General Hospital (some licensed to Promab) and the University of Pennsylvania (some licensed to Novartis); receives grant and research support from Kite Pharma; has served as a consultant for multiple companies involved in adoptive cell therapies; holds equity in 2SeventyBio, Century Therapeutics, Neximmune, Oncternal and TCR2; and is part of the board of directors for 2Seventy Bio. M.B.L. declares no competing interests.
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Leick, M.B., Maus, M.V. Multiomics STEP up in correlative analysis of response to CAR T cells. Nat Rev Clin Oncol 20, 285–286 (2023). https://doi.org/10.1038/s41571-023-00742-5