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GPRC5D as a novel immunotherapeutic target in multiple myeloma

The development of modern immune-based therapies for multiple myeloma has expanded rapidly over the past several years, and GPRC5D has been identified as a viable immunotherapeutic target. Herein, we discuss data and provide future perspectives on GPRC5D-directed CAR T cells and bispecific antibodies for patients with relapsed and/or refractory multiple myeloma.

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K.N. and S.M. gratefully acknowledge the US National Cancer Institute Cancer Centre Support Grant (P30 CA008748) to Memorial Sloan Kettering Cancer Centre.

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Correspondence to Sham Mailankody.

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Competing interests

S.M. has acted as a consultant of Evicore, Janssen, Legend Biotech and Optum Oncology, receives honoraria from MJH Life sciences, Physician Education Resource and Plexus Education, and acknowledges research funding from Allogene Therapeutics Bristol Myers Squibb, Fate Therapeutics, Janssen Oncology, Juno Therapeutics and Takeda Oncology. K.N. and B.A.C. declare no competing interests.

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Nath, K., Costa, B.A. & Mailankody, S. GPRC5D as a novel immunotherapeutic target in multiple myeloma. Nat Rev Clin Oncol (2023).

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