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Haematological cancer

Promise with co-administration of CAR T cells

Nature Reviews Clinical Oncology volume 20, page 1 (2023)Cite this article

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Disease relapse in paediatric patients with B cell acute lymphoblastic leukaemia (B-ALL) receiving CD19-targeted chimeric antigen receptor (CAR) T cells is generally associated with loss of CAR T cell persistence and/or loss of CD19 expression. To overcome this limitation, several sequential or combinatorial approaches using CD22-targeted CAR T cells have been tested; however, responses are usually not durable. Now, data from a phase II trial reveal that co-administration of CD19-targeted and CD22-targeted CAR T cells is safe and effective in relapsed and/or refractory (R/R) B-ALL.

A total of 78 patients underwent consolidative transplantation, which was associated with improved EFS (85.0% versus 69.2% without transplantation; P = 0.03) but not with significant differences in OS (91.3% versus 85.0%; P = 0.4) at 12 months.

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  1. Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc

    Diana Romero

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  1. Diana Romero
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Correspondence to Diana Romero.

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Romero, D. Promise with co-administration of CAR T cells. Nat Rev Clin Oncol 20, 1 (2023). https://doi.org/10.1038/s41571-022-00713-2

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  • DOI: https://doi.org/10.1038/s41571-022-00713-2

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