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Are the chronological age cutoffs used in clinical oncology guidelines biologically meaningful?

Age is one of the strongest risk factors for cancer and also affects tumour biology, treatment recommendations and response to therapy. Although clinical oncology guidelines advocate against classifying patients on the basis of chronological age alone, most studies and published guidelines use discrete age cutoffs, often heterogeneously. Herein, we discuss age cutoffs from a historical and biological perspective, focusing on breast cancer.

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N.C. receives funding from the National Cancer Institute of the National Institutes of Health (award number 1F30CA264963-01).

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Correspondence to Priscilla F. McAuliffe.

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Carleton, N., McAuliffe, P.F. Are the chronological age cutoffs used in clinical oncology guidelines biologically meaningful?. Nat Rev Clin Oncol 19, 745–746 (2022).

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