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Overall survival as a primary end point in multiple myeloma trials

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Median overall survival for patients with newly diagnosed multiple myeloma may surpass ten years. Nonetheless, many patients face considerable treatment-related morbidity and relapsed disease. Owing to this typically long overall survival, most multiple myeloma trials now use progression-free survival as their primary end point. In this Comment, we highlight circumstances in which this end point does not best answer the questions that various trials seek to investigate.

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  • 31 May 2023

    In the version of this article initially published, the given name and surname for Ghulam Rehman Mohyuddin were presented incorrectly and are now amended in the online version of the article.


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Correspondence to Edward R. Scheffer Cliff.

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Cliff, E.R.S., Mohyuddin, G.R. Overall survival as a primary end point in multiple myeloma trials. Nat Rev Clin Oncol 19, 565–566 (2022).

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