Immune-checkpoint inhibitors have revolutionized the treatment of patients with non-small-cell lung cancer (NSCLC). Recently, indications for immune-checkpoint inhibitors have expanded from advanced-stage NSCLC to adjuvant, and now neoadjuvant, therapy for resectable NSCLC, with three cycles of preoperative chemoimmunotherapy achieving superior pathological complete response rates and event-free survival compared with chemotherapy alone in the phase III CheckMate 816 trial.
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The authors thank T. Cascone (The University of Texas MD Anderson Cancer Center) for her expertise and consultation regarding this article.
B.S. has received speaker’s fees from AstraZeneca and Peer View, and consultation fees from AstraZeneca and Medscape. S.S. declares no competing interests.
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Sepesi, B., Swisher, S.G. Role of neoadjuvant chemoimmunotherapy for resectable NSCLC. Nat Rev Clin Oncol 19, 497–498 (2022). https://doi.org/10.1038/s41571-022-00647-9