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Value-based pricing of drugs with multiple indications or in combinations — lessons from Europe

Legislators in the USA have been discussing reforms to reduce the high cost of brand-name drugs, which are much higher in the USA than in other industrialized countries. One solution is to actively negotiate prices based on drugs’ clinical benefits. We discuss two important complexities from such an approach: drugs that have been approved for multiple indications and as part of a combination regimen.

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The authors are grateful to David L. Carl (University of Zurich) for assistance with a previous version of the manuscript. The work of K.N.V. is partially funded by the Swiss National Science Foundation (SNSF). The work of A.S.K. is supported by Arnold Ventures.

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Correspondence to Kerstin N. Vokinger.

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The authors declare no competing interests.

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Vokinger, K.N., Kesselheim, A.S. Value-based pricing of drugs with multiple indications or in combinations — lessons from Europe. Nat Rev Clin Oncol (2021).

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