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The ten genes for breast (and ovarian) cancer susceptibility

ATM, BRCA1, BRCA2, CHEK2, PALB2 and TP53 are all established breast cancer susceptibility genes. Over the past 30 years, many other genes have been proposed as candidates. In these two large studies, the candidacy of several questionable genes has been largely resolved, and a final list of ten genes for breast and, importantly, ovarian cancer risk has emerged.

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  1. Hall, J. M. et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684–1689 (1990).

    Article  CAS  Google Scholar 

  2. Foulkes, W. D. & Polak, P. Journey’s end: the quest for BRCA-like hereditary breast cancer genes is nearly over. Ann. Oncol. 30, 1023–1025 (2019).

    Article  CAS  Google Scholar 

  3. Breast Cancer Association Consortium. Breast cancer risk genes — association analysis in more than 113,000 women. N. Engl. J. Med. 384, 428–439 (2021).

    Article  Google Scholar 

  4. Hu, C. et al. A population-based study of genes previously implicated in breast cancer. N. Engl. J. Med. 384, 440–451 (2021).

    Article  Google Scholar 

  5. Easton, D. et al. Gene-panel sequencing and the prediction of breast-cancer risk. New Engl. J. Med. 372, 2243–2257 (2015).

    Article  CAS  Google Scholar 

  6. Kuchenbaecker, K. B. et al. Risks of Breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA 317, 2402–2416 (2017).

    Article  CAS  Google Scholar 

  7. Hughley, R. et al. Etiologic Index - A Case-Only Measure of BRCA1/2-Associated Cancer Risk. N. Engl. J. Med. 383, 286–288 (2020).

    Article  Google Scholar 

  8. Zhao, W., Wiese, C., Kwon, Y., Hromas, R. & Sung, P. The BRCA tumor suppressor network in chromosome damage repair by homologous recombination. Annu. Rev. Biochem. 88, 221–245 (2019).

    Article  CAS  Google Scholar 

  9. Ramus, S. J. et al. Germline mutations in the BRIP1, BARD1, PALB2, and NBN genes in women with ovarian cancer. J. Natl Cancer. Inst. 107, djv214 (2015).

    Article  Google Scholar 

  10. Foulkes, W. D., Knoppers, B. M. & Turnbull, C. Population genetic testing for cancer susceptibility: founder mutations to genomes. Nat. Rev. Clin. Oncol. 13, 41–54 (2016).

    Article  CAS  Google Scholar 

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Correspondence to William D. Foulkes.

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Foulkes, W.D. The ten genes for breast (and ovarian) cancer susceptibility. Nat Rev Clin Oncol 18, 259–260 (2021).

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