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Advancing oncolytic virus therapy by understanding the biology

Talimogene laherparepvec (T-VEC) is an oncolytic virus approved for the treatment of patients with recurrent melanoma. Now, a recent study in patients with primary cutaneous B cell lymphoma confirms prior results in melanoma and reveals new mechanisms of action. Herein, we discuss these findings and their implications for expanding the role of oncolytic viruses.

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Fig. 1: Multimodal mechanisms of action associated with oncolytic virus therapy.


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The authors wish to thank G. Iodice for helpful conversations and review of the manuscript.

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Correspondence to Howard L. Kaufman.

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H.L.K. is an employee of Immuneering Corp. D.M. declares no competing interests.

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Kaufman, H.L., Maciorowski, D. Advancing oncolytic virus therapy by understanding the biology. Nat Rev Clin Oncol 18, 197–198 (2021).

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