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IMMUNOTHERAPY

Advancing oncolytic virus therapy by understanding the biology

Nature Reviews Clinical Oncology volume 18, pages 197–198 (2021)Cite this article

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Talimogene laherparepvec (T-VEC) is an oncolytic virus approved for the treatment of patients with recurrent melanoma. Now, a recent study in patients with primary cutaneous B cell lymphoma confirms prior results in melanoma and reveals new mechanisms of action. Herein, we discuss these findings and their implications for expanding the role of oncolytic viruses.

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Fig. 1: Multimodal mechanisms of action associated with oncolytic virus therapy.

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Acknowledgements

The authors wish to thank G. Iodice for helpful conversations and review of the manuscript.

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Authors and Affiliations

  1. Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA

    Howard L. Kaufman & Dawid Maciorowski

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  1. Howard L. Kaufman
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  2. Dawid Maciorowski
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Correspondence to Howard L. Kaufman.

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Competing interests

H.L.K. is an employee of Immuneering Corp. D.M. declares no competing interests.

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Kaufman, H.L., Maciorowski, D. Advancing oncolytic virus therapy by understanding the biology. Nat Rev Clin Oncol 18, 197–198 (2021). https://doi.org/10.1038/s41571-021-00490-4

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