A role for extracellular vesicles and particles (EVPs) as cancer biomarkers has been elusive. A mass spectrometry-based comparative analysis of EVPs from individuals with or without cancer has now enabled the identification of tumour-associated protein profiles in EVPs in plasma and paired tumour tissues, validating the role of EVPs as a novel liquid biopsy approach in cancer diagnosis.
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Acknowledgements
T.L.W.’s research is supported in part by NIH grants R01 CA168626, U01 DE029759 and SBIR 75N91019C00042.
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Whiteside, T.L. Validation of plasma-derived small extracellular vesicles as cancer biomarkers. Nat Rev Clin Oncol 17, 719–720 (2020). https://doi.org/10.1038/s41571-020-00433-5
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DOI: https://doi.org/10.1038/s41571-020-00433-5
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