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Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?

Breast oncologists are intimately familiar with managing treatment-related adverse events of endocrine, cytotoxic and targeted therapies, but the approval of immune-checkpoint inhibitors (ICIs) for metastatic triple-negative breast cancer (TNBC) poses new challenges. Herein, we discuss the safety of ICIs in metastatic TNBC, with an emphasis on immune-related adverse events.

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Correspondence to Sylvia Adams.

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Competing interests

S.A. declares that she has received research funding to her institution from Merck, Genentech, Amgen, Celgene, Bristol-Myers Squibb (BMS) and Novartis and that she is a Steering committee member for IMpassion130 (uncompensated), a Global PI on Keynote-086 (uncompensated) and a consultant for BMS (uncompensated). N.D’A. declares no competing interests.

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D’Abreo, N., Adams, S. Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?. Nat Rev Clin Oncol 16, 399–400 (2019). https://doi.org/10.1038/s41571-019-0216-2

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