Chemoprevention of Barrett’s oesophagus: a step closer with PPIs and aspirin

Chemoprevention for patients with Barrett’s oesophagus remains a controversial topic. Results of the first randomized trial of chemoprevention using a proton pump inhibitor with or without aspirin were recently reported. We highlight strengths and weaknesses in the design of the trial and discuss the clinical implications of the findings.

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The work of the authors is also supported in part by the NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Center for Gastrointestinal Development, Infection, and Injury (grant P30DK56338).

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Correspondence to Hashem B. El-Serag.

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The authors declare no competing interests.

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Husain, N.S., El-Serag, H.B. Chemoprevention of Barrett’s oesophagus: a step closer with PPIs and aspirin. Nat Rev Clin Oncol 15, 728–730 (2018).

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